Proposition 65
  Proposition 65
Since the early 1990’s, Cambridge Environmental has provided high-level technical expertise to parties involved in California Proposition 65 issues and assessments. Our experienced engineers, physical scientists, and life scientists work together to provide exposure assessments that are sophisticated and accurate. Such assessments can be used by parties considering filing claims of significant risk to health, as well as by parties defending against such claims. We are expert at assessing all relevant behaviors, scenarios, and routes of exposure — inhalation, ingestion, and absorption across skin. For each scenario and route of exposure, we search for empirical data (either on the chemical of interest or on reasonable surrogate chemicals), determine whether additional test data are desired and/or required, and develop and apply mathematical models to make best estimates of doses to consumers, workers, and others. Often, these models — whether of the fate and transport of chemicals in indoor air, for example, or of chemical-uptake by people exposed in various ways — are not straightforward. Modeling dermal exposure from a cosmetic, lotion, or aqueous solution, for example, typically involves approximate solutions of a differential equation for diffusion through skin, combined with analysis of, and comparison with, a large experimental database on dermal permeation of chemicals. Our ability to use and document such techniques is central to our producing high-quality assessments and reports.

When existing data and models are insufficient, we are also adept at designing and implementing (or overseeing the implementation of) experiments to generate required information.

Our board-certified toxicologists are also skilled in analyzing and extrapolating dose-response data in order to comment intelligently and compellingly on proposed “no significant risk levels” and “maximum allowable dose levels.”

Most of our work in this area cannot be freely disseminated, due to confidential business information of our clients. However, a “sanitized” version of an analysis we recently completed with regard to dishwashing liquids that contain part-per-billion concentrations of 1,4-dioxane (a confirmed carcinogen in laboratory rodents, and a presumed carcinogen in people), is available by clicking on the link below.

Dishwashing liquid Proposition 65 risk evaluation

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